By InvitationNot Applicable

RCT - Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy

Thailand40 participantsStarted 2024-09-01

Plain-language summary

Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times. The primary outcome was to compare intraoperative blood loss between patients who received intravenous Vitamin C and those who did not, following an abdominal hysterectomy under general anesthesia. Intraoperative estimated blood loss (EBL) was meticulously quantified by weighing surgical gauze and measuring suction canister volumes. The secondary outcomes were to evaluate the potential benefits of Vitamin C administration, including: * Reduction in the decline of hematocrit levels after surgery. * Reduction of the length of hospital stay

Who can participate

Age range20 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female patients who underwent total abdominal hysterectomy * No bleeding tendency. * No history of anticoagulant or thrombolytic drug use * No contraindications to vitamin C supplementation Exclusion Criteria: * Inability to communicate in the Thai language. * Underwent total abdominal hysterectomy due to gynecologic malignancy. * Required emergency total abdominal hysterectomy. * History of vitamin C supplementation within 2 weeks prior to surgery. * History of smoking. * Previous abdominal surgery, such as bowel surgery, cesarean section

What they're measuring

Intraoperative estimate blood loss

Timeframe: intraoperative

Trial details

NCT IDNCT07335432

SponsorQueen Savang Vadhana Memorial Hospital, Thailand

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-31