Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy (NCT07335250) | Clinical Trial Compass
RecruitingNot Applicable
Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy
Turkey (Türkiye)66 participantsStarted 2026-04-08
Plain-language summary
This prospective, randomized, triple-blind, placebo-controlled clinical trial will investigate the effectiveness of the intertransverse process block (ITPB) for postoperative analgesia in patients undergoing elective thoracotomy with unilateral lobectomy. The study will be conducted at a single tertiary center in accordance with the principles of the Declaration of Helsinki, and written informed consent will be obtained from all participants.
Patients will be randomized in a 1:1 ratio to receive either ultrasound-guided ITPB with 0.5% bupivacaine or placebo (normal saline) prepared in identical syringes to ensure allocation concealment. The block will be performed by an experienced anesthesiologist immediately after surgery and before emergence from anesthesia. Both groups will receive standardized general anesthesia, multimodal perioperative analgesia, and postoperative intravenous morphine patient-controlled analgesia (PCA).
The trial aims to evaluate the analgesic efficacy and opioid-sparing effect of ITPB while maintaining safety and adherence to routine clinical practice. Outcomes will include postoperative pain scores, opioid consumption, rescue analgesia requirement, and adverse events.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Provision of written informed consent
Age between 18 and 85 years
ASA Physical Status classification I-III
Elective thoracotomy with planned unilateral lobectomy
Anticipated hospital stay of at least one night
Expected requirement for parenteral opioid analgesia for at least 24 hours postoperatively
Ability to operate an intravenous patient-controlled analgesia (PCA) device
Exclusion Criteria:
* Patients undergoing emergency surgery
Presence of infection or open wound at the injection site
Coagulopathy
Hepatic or renal failure
Patients undergoing reoperation
Patients with missing or incomplete data
Pregnancy or lactation
Tracheal malformation or tracheostomy
Chronic opioid use (≥30 days within the last 3 months, ≥15 mg/day morphine equivalent)
Patients exceeding the maximum safe local anesthetic dose based on weight (2.5 mg/kg, max 150 mg)
Patients who refuse data privacy consent will be excluded from the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Morphine Consumption Within the First 24 Hours After Surgery