Diagnostic Performance of PIC Cystogram vs VCUG in Children (NCT07334821) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Diagnostic Performance of PIC Cystogram vs VCUG in Children
Turkey (Türkiye)60 participantsStarted 2026-02-01
Plain-language summary
The goal of this interventional diagnostic clinical trial is to evaluate and compare the diagnostic effectiveness of PIC cystography and voiding cystourethrography (VCUG) for the detection of vesicoureteral reflux (VUR) in children undergoing endoscopic procedures, including those who previously underwent VCUG for urinary tract infection (UTI) or other indications, as well as children who did not require VCUG.
The main questions it aims to answer are:
Does PIC cystography detect VUR at a rate comparable to VCUG?
How well do PIC cystography and VCUG correlate in identifying low-grade versus high-grade VUR?
Researchers will compare PIC cystography findings with prior VCUG results to determine agreement between the two diagnostic methods and their ability to detect clinically relevant reflux.
Participants will:
Undergo PIC cystography performed during endoscopic surgery
Have contrast instilled near each ureteral orifice under fluoroscopic monitoring
Be evaluated for the presence and grade of vesicoureteral reflux
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Children aged 0-18 years
* Undergoing endoscopic urological surgery
* With or without a prior VCUG performed for urinary tract infection or other clinical indications
* Availability of VCUG results for participants who previously underwent VCUG
* Written informed consent obtained from parents or legal guardians
Exclusion Criteria:
* History of previous ureteral reimplantation or anti-reflux surgery
* Known neurogenic bladder or severe lower urinary tract dysfunction
* Active urinary tract infection at the time of endoscopic procedure
* Inability to undergo fluoroscopic imaging (e.g., contrast allergy)
* Incomplete clinical or imaging data
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is comparing PIC cystography with VCUG for detecting vesicoureteral reflux in children — can you explain what the practical difference between these two procedures is, and why it matters which one is used for my child's diagnosis?
2Since this trial isn't recruiting yet, what options exist right now for getting my child evaluated for vesicoureteral reflux, and would a standard VCUG be the appropriate next step in the meantime?
3The trial is listed as 'Not Yet Recruiting' — do you have any sense of when it might open, and would waiting to potentially participate change anything about my child's current care plan?
4PIC cystography seems to be a newer or less commonly used approach compared to VCUG — based on what's already known about both procedures, are there any differences in radiation exposure, discomfort, or accuracy that I should be thinking about for my child?
5If my child ends up being evaluated through this study, would their diagnosis and treatment decisions still happen on the same timeline as if they went through standard care outside the trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Detection of vesicoureteral reflux (VUR) by PIC cystography compared with VCUG
Timeframe: During endoscopic surgery (single intraoperative assessment)