Not Yet RecruitingNot Applicable

Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study

600 participantsStarted 2026-05

Plain-language summary

Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after pregnancy. Currently, the two main options for treating this pain are general anesthesia (full medically induced unconsciousness) and using intravenous medications to reduce the pain and decrease anxiety. The EAGLET-CS Pilot is a pilot randomized trial that will test the feasibility of comparing the impact of these two options for preventing PTSD in a rigorous way for those patients who experience pain during their cesarean section after the baby is out.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women aged 18 or older undergoing non-emergent cesarean delivery with primary neuraxial (epidural, spinal, or CSE) anesthesia. Eligible patients will be those who report severe pain during surgery, defined as pain that does not resolve with 2 trials of first-line pharmacologic therapies (e.g., epidural supplementation with local anesthetics; intravenous opioid analgesics). Exclusion Criteria: * We will exclude patients who require induction of general anesthesia prior to umbilical cord clamping and by clinician determination.

What they're measuring

Consent

Timeframe: From hospital admission through day of delivery

Trial details

NCT IDNCT07334418

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-11

Contact for this trial

Mark Neuman, MD

215-746-7468 eagletadmin@pennmedicine.upenn.edu

View on ClinicalTrials.gov More Cesarean Section trials