CompletedNot Applicable

Comparison of Preoxygenation Techniques in Healthy Volunteers With Monitoring of End-tidal Oxygen Fraction (FeO₂) and Oxygen Reserve Index (ORI)

France30 participantsStarted 2026-03-09

Plain-language summary

The objective of this physiological study is to compare two preoxygenation techniques (non-invasive ventilation combined with high-flow nasal oxygen versus non-invasive ventilation alone) by monitoring end-tidal oxygen fraction (FeO₂) and the Oxygen Reserve Index (ORI) during 3 minutes of preoxygenation in healthy volunteers.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female * Healthy volunteer who has provided written informed consent * Age \> 18 years Exclusion Criteria: * Long-term oxygen therapy * Cardiac or pulmonary disease (including asthma) * Presence of Raynaud's syndrome * Claustrophobia * Body mass index (BMI) ≥ 30 kg/m² * Presence of nail polish preventing accurate SpO₂ and ORI measurement * Under legal protection * Incarcerated individuals * Persons deprived of liberty * Not affiliated to French social security * Pregnant or breastfeeding women * Individuals currently participating in a drug study and still within the exclusion period

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in end-tidal oxygen fraction (FeO2) at the end of each preoxygenation technique

Timeframe: 3 minutes

Trial details

NCT IDNCT07334041

SponsorCentre Hospitalier Régional d'Orléans

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-29

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