RecruitingNot Applicable

Comparison of Preoxygenation Techniques in Healthy Volunteers With Monitoring of End-tidal Oxygen Fraction (FeO₂) and Oxygen Reserve Index (ORI)

France30 participantsStarted 2026-03-09

Plain-language summary

The objective of this physiological study is to compare two preoxygenation techniques (non-invasive ventilation combined with high-flow nasal oxygen versus non-invasive ventilation alone) by monitoring end-tidal oxygen fraction (FeO₂) and the Oxygen Reserve Index (ORI) during 3 minutes of preoxygenation in healthy volunteers.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female * Healthy volunteer who has provided written informed consent * Age \> 18 years Exclusion Criteria: * Long-term oxygen therapy * Cardiac or pulmonary disease (including asthma) * Presence of Raynaud's syndrome * Claustrophobia * Body mass index (BMI) ≥ 30 kg/m² * Presence of nail polish preventing accurate SpO₂ and ORI measurement * Under legal protection * Incarcerated individuals * Persons deprived of liberty * Not affiliated to French social security * Pregnant or breastfeeding women * Individuals currently participating in a drug study and still within the exclusion period

What they're measuring

Change in end-tidal oxygen fraction (FeO2) at the end of each preoxygenation technique

Timeframe: 3 minutes

Trial details

NCT IDNCT07334041

SponsorCentre Hospitalier Régional d'Orléans

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02

Contact for this trial

Mai-Anh NAH, MD

+33238575253 maianh.nay@chu-orleans.fr

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