Not Yet RecruitingNot Applicable

Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU Patients

110 participantsStarted 2026-01-15

Plain-language summary

This prospective, non-interventional study aims to investigate the relationship between early oxygen exposure and oxidative stress in adult intensive care unit (ICU) patients diagnosed with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) levels administered during the first 24 hours of ICU admission will be evaluated in relation to changes in the uric acid/albumin ratio (UAR), a biochemical marker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at ICU admission and at 24 hours, and the percentage change in UAR (ΔUAR%) will be calculated. Associations between FiO₂ exposure parameters and ΔUAR% will be analyzed, along with secondary outcomes including 28-day mortality and oxygenation indices. The findings may help clarify whether excessive oxygen therapy contributes to oxidative stress and whether UAR can serve as an accessible biomarker of oxygen-related oxidative injury in septic ICU patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients aged 18 years or older * Admission to the intensive care unit with a diagnosis of sepsis according to Sepsis-3 criteria * Receipt of oxygen therapy with FiO₂ ≥ 0.3 during ICU stay * Availability of serum uric acid, albumin, and lactate measurements and calculated SOFA scores at ICU admission * Availability of serum uric acid and albumin levels both at ICU admission (baseline) and at 24 hours * Provision of informed consent by the patient or a legally authorized representative Exclusion Criteria: * Age younger than 18 years * Pregnant or breastfeeding women * Chronic kidney disease or receipt of renal replacement therapy * Advanced liver failure (Child-Pugh class C) * Receipt of albumin infusion within the previous 24 hours * Use of medications that affect uric acid metabolism (e.g., allopurinol, febuxostat, rasburicase) * History of active gout attack or malignancy-related hyperuricemia * Missing serum uric acid or albumin measurements at baseline or 24 hours * Inability to obtain informed consent from the patient or a legally authorized representative

What they're measuring

Change in Uric Acid/Albumin Ratio in Relation to Early FiO₂ Exposure

Timeframe: From ICU admission (0 hour) to 24 hours after admission

Trial details

NCT IDNCT07332637

SponsorIstinye University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-05-15

Contact for this trial

İLKE DOLĞUN

+905555485632 ilkeser2004@gmail.com