Not Yet RecruitingNot Applicable

A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly-Diagnosed Stage I-IIIa Breast Cancer, MAMA Trial

United States10 participantsStarted 2026-08-07

Plain-language summary

This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer. Compared to non-Hispanic White breast cancer survivors (BCS), Hispanic BCS report greater depressive symptoms, emotional distress, anxiety, fear of recurrence, pain, fatigue, and financial toxicity, in addition to more cancer-related psychosocial needs and lower quality of life and social well-being. Cancer-associated cognitive decline (CACD) is a related symptom that has gained increasing attention in clinical research. Based on disparities in other outcomes, it is likely that Hispanic BCS also experience greater CACD than non-Hispanic White BCS, but interventions targeting CACD in Hispanic BCS are non-existent and critically needed. The benefits of aerobic exercise among BCS are well documented and include improvement in health outcomes that are associated with cognitive function including fatigue, anxiety, depression, and sleep. A physical activity program that includes aerobic exercise may be more effective than simple health education for improving cognitive functions like memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.

Who can participate

Age range50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * PRE-REGISTRATION: Age \>= 50 years at time of pre-registration visit according to participant report and/or clinical determination * PRE-REGISTRATION: Self-identifies as Hispanic (any race) * PRE-REGISTRATION: First time, primary diagnosis of Stage I-IIIa breast cancer according to participant report and/or clinical determination * PRE-REGISTRATION: Post-surgery and completed primary adjuvant treatment (i.e., surgery, chemotherapy, and/or radiation therapy) 3-36 months prior to preregistration according to participant report and/or clinical determination * PRE-REGISTRATION: Sedentary except for casual lifestyle recreation, self-reporting no more than 90 minutes per week of moderate-intensity aerobic exercise within the last 6 months * PRE-REGISTRATION: Self-reported ability to complete assessments by themselves or with assistance * REGISTRATION: Age \>= 50 years or older as confirmed via clinical determination * REGISTRATION: Self-identifies as Hispanic (any race) * REGISTRATION: Able to provide medical record release to confirm eligibility * REGISTRATION: First time, primary diagnosis of Stage I-IIIa breast cancer as confirmed via clinical determination * REGISTRATION: Post-surgery and completed primary treatment (i.e., surgery, chemotherapy, and/or radiation therapy) 3-36 months prior to pre-registration as confirmed via clinical determination * REGISTRATION: No evidence of possible cognitive impairment as assessed using the Telephone Interview of Cog…

What they're measuring

Change in inhibitory control

Timeframe: Baseline to post-intervention (month 6)

Change in cognitive flexibility

Timeframe: Baseline to post-intervention (month 6)

Change in executive function processing

Timeframe: Baseline to post-intervention (month 6)

Change in short-term memory

Timeframe: Baseline to post-intervention (month 6)

Change in verbal memory

Timeframe: Baseline to post-intervention (month 6)

Change in working memory

Timeframe: Baseline to post-intervention (month 6)

Change in processing speed

Timeframe: Baseline to post-intervention (month 6)

Change in attention

Timeframe: Baseline to post-intervention (month 6)

Trial details

NCT IDNCT07331077

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-11-30

Contact for this trial

Clinical Trials Referral Office

855-776-0015 mayocliniccancerstudies@mayo.edu

View on ClinicalTrials.gov More Anatomic Stage I Breast Cancer AJCC v8 trials

Plain-language summary

Who can participate

Age range50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in inhibitory control

Timeframe: Baseline to post-intervention (month 6)

Change in cognitive flexibility

Timeframe: Baseline to post-intervention (month 6)

Change in executive function processing

Timeframe: Baseline to post-intervention (month 6)

Change in short-term memory

Timeframe: Baseline to post-intervention (month 6)

Change in verbal memory

Timeframe: Baseline to post-intervention (month 6)

Change in working memory

Timeframe: Baseline to post-intervention (month 6)

Change in processing speed

Timeframe: Baseline to post-intervention (month 6)

Change in attention

Timeframe: Baseline to post-intervention (month 6)