A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hi… (NCT07331077) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly-Diagnosed Stage I-IIIa Breast Cancer, MAMA Trial
United States10 participantsStarted 2026-10-01
Plain-language summary
This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer. Compared to non-Hispanic White breast cancer survivors (BCS), Hispanic BCS report greater depressive symptoms, emotional distress, anxiety, fear of recurrence, pain, fatigue, and financial toxicity, in addition to more cancer-related psychosocial needs and lower quality of life and social well-being. Cancer-associated cognitive decline (CACD) is a related symptom that has gained increasing attention in clinical research. Based on disparities in other outcomes, it is likely that Hispanic BCS also experience greater CACD than non-Hispanic White BCS, but interventions targeting CACD in Hispanic BCS are non-existent and critically needed. The benefits of aerobic exercise among BCS are well documented and include improvement in health outcomes that are associated with cognitive function including fatigue, anxiety, depression, and sleep. A physical activity program that includes aerobic exercise may be more effective than simple health education for improving cognitive functions like memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.
Who can participate
Age range
50 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* PRE-REGISTRATION: Age \>= 50 years at time of pre-registration visit according to participant report and/or clinical determination
* PRE-REGISTRATION: Self-identifies as Hispanic (any race)
* PRE-REGISTRATION: First time, primary diagnosis of Stage I-IIIa breast cancer according to participant report and/or clinical determination
* PRE-REGISTRATION: Post-surgery and completed primary adjuvant treatment (i.e., surgery, chemotherapy, and/or radiation therapy) 3-36 months prior to preregistration according to participant report and/or clinical determination
* PRE-REGISTRATION: Sedentary except for casual lifestyle recreation, self-reporting no more than 90 minutes per week of moderate-intensity aerobic exercise within the last 6 months
* PRE-REGISTRATION: Self-reported ability to complete assessments by themselves or with assistance
* REGISTRATION: Age \>= 50 years or older as confirmed via clinical determination
* REGISTRATION: Self-identifies as Hispanic (any race)
* REGISTRATION: Able to provide medical record release to confirm eligibility
* REGISTRATION: First time, primary diagnosis of Stage I-IIIa breast cancer as confirmed via clinical determination
* REGISTRATION: Post-surgery and completed primary treatment (i.e., surgery, chemotherapy, and/or radiation therapy) 3-36 months prior to pre-registration as confirmed via clinical determination
* REGISTRATION: No evidence of possible cognitive impairment as assessed using the Telephone Interview of Cog…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial specifically targets Hispanic women with newly-diagnosed Stage I through IIIA breast cancer, could you help me understand whether my background, diagnosis stage, and current treatment plan would even make this worth exploring once it opens to recruitment?
2This trial is comparing a physical activity program to a health education program for memory and attention problems related to cancer treatment — sometimes called 'chemo brain' — so could you tell me how significant that kind of cognitive side effect tends to be with the treatment you're recommending for me, and whether it's something I should be actively trying to address?
3The trial is listed as 'not yet recruiting,' so if I'm interested, how would we time that conversation given that my cancer treatment may need to start soon, and could waiting to enroll potentially conflict with getting started on standard care?
4This study is measuring things like brain volume, white matter integrity, and resting-state brain connectivity through what are likely brain imaging tests — could you walk me through what that level of testing commitment would actually look like in my schedule on top of my regular cancer treatment?
5Since this trial is in a non-standard phase focused on measuring cognitive outcomes rather than testing a new drug or procedure, what does that mean for what's already known about the safety and benefit of a structured physical activity program during breast cancer treatment, and is there any reason you'd recommend I just pursue exercise on my own instead?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in inhibitory control
Timeframe: Baseline to post-intervention (month 6)
2
Change in cognitive flexibility
Timeframe: Baseline to post-intervention (month 6)
3
Change in executive function processing
Timeframe: Baseline to post-intervention (month 6)
4
Change in short-term memory
Timeframe: Baseline to post-intervention (month 6)
5
Change in verbal memory
Timeframe: Baseline to post-intervention (month 6)
6
Change in working memory
Timeframe: Baseline to post-intervention (month 6)
7
Change in processing speed
Timeframe: Baseline to post-intervention (month 6)