CompletedNot Applicable

Different Norepinephrine Doses on Accuracy of Peripheral Perfusion Index in Predicting Tissue Perfusion in Septic Shock Patients

Egypt80 participantsStarted 2024-10-30

Plain-language summary

This study aims to evaluate the impact of different norepinephrine doses on the accuracy of the peripheral perfusion index in predicting tissue perfusion in septic shock patients. Primary outcome: * Correlation between peripheral perfusion index Secondary outcomes: * Peripheral perfusion index accuracy to predict the tissue perfusion . * Peripheral perfusion index accuracy to predict mortality.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 to 65 years. * Both sexes. * Septic shock patients requiring norepinephrine infusion at dose \<0.25 µg/kg/min to achieve mean arterial pressure (Mean arterial blood pressure ≥ 65 mm Hg). Exclusion Criteria: * Patients fail to achieve Mean arterial blood ≥ 65 mm Hg or need norepinephrine dose ≥0.25 µg /kg/min. * Pregnancy. * Diabetes mellitus. * Tissue edema. * Respiratory diseases affecting gas exchange, such as asthma and Chronic Obstructive Pulmonary Disease. * Sever hypoxemia or hypercarbia. * Core temperature \< 36 ᴼc. * Body mass index ≥35 kg/m2 * Cardiovascular diseases and pulmonary edema

What they're measuring

Correlation between Peripheral Perfusion Index and ( Central venous oxygen saturation , and lactate clearance).

Timeframe: Before initiation of vasopressor therapy, 5 minutes, 30 minutes, 1 hour, 2 hours, and 6 hours post-initiation of vasopressor therapy

Trial details

NCT IDNCT07330908

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-30

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