Not Yet RecruitingPhase 3

Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia

50 participantsStarted 2026-01-20

Plain-language summary

In this study the participants aim to Compare The Effect of Intravenous Combination Dexmedetomidine \_ Ketamine versus Dexmedetomidine on Post-Operative Analgesia In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.

Who can participate

Age range21 Years – 65 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who will accept written informed consent. * Age: 21-65 years old. * Sex: female. * BMI: \<35 kg/m2 * Physical status: American Society of Anesthesiology (ASA) of Grade I-II * Type of operation: vaginal hysterectomy under spinal anesthesia. Exclusion Criteria: * Uncooperative patients * Any contraindication for spinal anesthesia e.g. coagulopathy, infection at site of block, and hypersensitivity to any drug used in this study. * Patients who are known to be drug dependent.

What they're measuring

Assess the postoperative analgesic requirements in first 24 hours.

Timeframe: Pain grade of patients will be evaluated immediately on arrival to PACU then at 2, 4, 6,12, 24 hours postoperatively

Trial details

NCT IDNCT07330375

SponsorZagazig University

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-06-15

Contact for this trial

Abdelrahman Elsayed Amer, Resident of Anesthesia

00201024172506 ae.amer025@medicine.zu.edu.eg

View on ClinicalTrials.gov More Postoperative Analgesia trials