Comparison of Classic and Sequential Spinal Techniques for Preventing Hypotension During Cesarean… (NCT07327866) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Comparison of Classic and Sequential Spinal Techniques for Preventing Hypotension During Cesarean Delivery.
Egypt94 participantsStarted 2026-01-28
Plain-language summary
Given the clinical importance of maternal hypotension, the potential advantages of sequential spinal dosing warrant formal evaluation in a prospective, adequately powered randomized controlled trial. We therefore designed this study to compare the incidence of post-spinal hypotension between the classic single-shot spinal and the sequential fractionated spinal techniques in elective cesarean delivery.
Who can participate
Age range
18 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult women aged 18-45 years.
* ASA physical status II-III.
* Scheduled for elective cesarean section under standardized spinal anesthesia.
Exclusion Criteria:
* Allergy to local anesthetics.
* Emergency cesarean section.
* Contraindication to spinal anesthesia (e.g., coagulopathy, infection at the puncture site).
* Preexisting hypertension on medication or pre-eclampsia with severe features.
* Known cardiac disease accompanied by hemodynamic instability.
* Allergy to study drugs.
* Fetal distress or non-reassuring cardiotocography (CTG).
* BMI \>40 kg/m².
* Refusal to sign informed consent.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of post-spinal hypotension
Timeframe: Assessed during the first 15 minutes after the intrathecal injection.