Not Yet RecruitingPhase 3

Comparison of Classic and Sequential Spinal Techniques for Preventing Hypotension During Cesarean Delivery.

Egypt94 participantsStarted 2026-01-28

Plain-language summary

Given the clinical importance of maternal hypotension, the potential advantages of sequential spinal dosing warrant formal evaluation in a prospective, adequately powered randomized controlled trial. We therefore designed this study to compare the incidence of post-spinal hypotension between the classic single-shot spinal and the sequential fractionated spinal techniques in elective cesarean delivery.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult women aged 18-45 years. * ASA physical status II-III. * Scheduled for elective cesarean section under standardized spinal anesthesia. Exclusion Criteria: * Allergy to local anesthetics. * Emergency cesarean section. * Contraindication to spinal anesthesia (e.g., coagulopathy, infection at the puncture site). * Preexisting hypertension on medication or pre-eclampsia with severe features. * Known cardiac disease accompanied by hemodynamic instability. * Allergy to study drugs. * Fetal distress or non-reassuring cardiotocography (CTG). * BMI \>40 kg/m². * Refusal to sign informed consent.

What they're measuring

Incidence of post-spinal hypotension

Timeframe: Assessed during the first 15 minutes after the intrathecal injection.

Trial details

NCT IDNCT07327866

SponsorAl-Azhar University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-30

Contact for this trial

Neveen A Kohaf, Ph.D

+201060383012 nevenabdo@azhar.edu.eg

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