By InvitationNot Applicable

Non-Invasive Brain-Computer Interface Combined With Transcranial Electrical Stimulation for Peripheral Facial PalsyStimulation in the Treatment of Peripheral Facial Palsy

China30 participantsStarted 2025-11-30

Plain-language summary

To evaluate the efficacy and safety of treating peripheral facial palsy using a non-invasive brain-computer interface combined with transcranial direct current stimulation (tDCS).

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Aged 18-70 years, regardless of sex. Unilateral peripheral facial nerve palsy. House-Brackmann (HB) grade II-VI. Able to cooperate with target facial movement tasks and provide written informed consent, with intact cognitive function and good communication ability. Good skin condition, with no severe skin lesions or facial skin grafts; no implanted electronic devices such as cardiac pacemakers or deep brain stimulators, to avoid electrophysiological interference. Non-pregnant and non-lactating women, in accordance with regulatory requirements for minimal-risk research. Exclusion Criteria: Open facial wounds, active infections, significant skin lesions, or a history of severe allergy. Severe cognitive impairment, psychiatric disorders, or inability to comply with study procedures. Occurrence of serious adverse events or withdrawal at the patient's request. Pregnant or lactating women, or patients unable to use appropriate contraceptive measures during the study period.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Improvement in House-Brackmann (HB) grading

Timeframe: At 0，2，4，8 and 12 weeks.

Sunnybrook Facial Grading System score.

Timeframe: At 0，2，4，8 and 12 weeks.

Static and dynamic facial symmetry scores.

Timeframe: At 0，2，4，8 and 12 weeks.

Degree of facial muscle EMG activation and changes in EEG functional connectivity.

Timeframe: At 0，2，4，8 and 12 weeks.

Trial details

NCT IDNCT07327710

SponsorNanjing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

View on ClinicalTrials.gov More Peripheral Facial Palsy trials

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Improvement in House-Brackmann (HB) grading

Timeframe: At 0，2，4，8 and 12 weeks.

Sunnybrook Facial Grading System score.

Timeframe: At 0，2，4，8 and 12 weeks.

Static and dynamic facial symmetry scores.

Timeframe: At 0，2，4，8 and 12 weeks.

Degree of facial muscle EMG activation and changes in EEG functional connectivity.

Timeframe: At 0，2，4，8 and 12 weeks.