The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.

Inclusion Criteria: * Patients diagnosed with axillary spondyloarthropathy according to ASAS diagnostic criteria, * Having a high disease severity (ASDAS-CRP above 2.1), * Being sedentary (not engaging in physical activity at least 3 days a week in the last 3 months), * Having no change in ankylosing spondylitis medical treatment in the last 3 months, * Not having any orthopedic, neurological, cardiovascular, or mental disease that would affect exercise, * Not using any assistive devices for ambulation, * Having a BMI of 25 kg/m2 or less, * Male and female patients aged 18-50 years. Exclusion Criteria: * Those with uncontrolled cardiopulmonary disease (such as hypertension, chronic obstructive pulmonary disease, heart failure), * Having comorbidities that reduce exercise capacity, * Pregnancy, * Malignancy, * Those with a recent history of surgery, * Those who have engaged in regular exercise (aquatic exercise, land exercise, etc.) in the previous 3 months