By InvitationNot Applicable

The Study of ENB With Ultra-thin Cryobiopsy in the Diagnosis of Peripheral Pulmonary Nodules

China228 participantsStarted 2025-09-05

Plain-language summary

To investigate the safety and efficacy of ultrafine cryoprobe biopsy by electromagnetic navigation bronchoscopy compared with biopsy forceps in the diagnosis of peripheral pulmonary nodules in a national multicenter randomized controlled trial

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. age 18 to 90 years;
✓. pulmonary nodules detected by chest CT, suspected malignant nodules or unknown cause should be confirmed by biopsy;
✓. chest CT showed that the nodule was located in the segmental bronchus and below, and the maximum diameter of the nodule was 8 mm to 30 mm.It was not accessible by conventional bronchoscopy;
✓. if chest CT showed multiple pulmonary nodules, one of the pulmonary nodules was selected as the target lesion.

Exclusion criteria

✕. contraindications to the bronchoscopy procedure;
✕. high risk of bleeding, such as bronchial artery penetration or suspected lung metastasis of renal cell carcinoma;
✕. electromagnetic source implanted in the body;
✕. contraindications to anesthesia;
✕. pregnant woman;
✕. participated in other studies within three months and did not withdraw or finish, affect the observation of this study;
✕. inability or unwillingness to provide informed consent or comply with the follow-up schedule.

What they're measuring

Diagnostic yield

Timeframe: follow-up for 12 months

Trial details

NCT IDNCT07326072

SponsorBeijing Chao Yang Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-01-31

View on ClinicalTrials.gov More Diagnosis trials