This is a small trial testing out a new approach before doing a bigger study. Researchers are observing a group of children/adolescents (ages 5-17) with acute lymphoblastic leukemia (ALL) and testing a physical activity and exercise program on a group of them who after 5 weeks of treatment show signs of weakness or frailty. Kids who are NOT losing muscle aren't part of the exercise trial - they're just monitored over time to see how they do. The goal: To see if an exercise program helps kids who are getting weaker from acute lymphoblastic leukemia treatment build back/maintain their strength, compared to kids who don't do the extra intervention. The study will also look at if this way of measuring muscle weakness works well for kids with cancer.
Age range
5 Years – 17 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Mean change in muscle mass of rectus femoris on muscle ultrasound
Timeframe: Baseline, 16 weeks
Mean change in grip strength with handheld dynamometry
Timeframe: 5 weeks, 16 weeks
Mean change in knee extension strength on handheld dynamometry
Timeframe: 5 weeks, 16 weeks
Mean change in lean muscle mass on Dual-Energy X-ray Absorptiometry (DEXA) scan
Timeframe: 5 weeks and 24 weeks
Qualitative acceptability
Timeframe: 16 weeks
Fidelity of the intervention
Timeframe: Post-randomisation through to the final intervention session [anticipated at 15 weeks]
Feasibility of the trial measured by recruitment rate
Timeframe: through study recruitment completion, approximately 15 months
Feasibility of the trial measured by lost recruitment opportunities
Timeframe: through study recruitment completion, approximately 15 months
Feasibility of the intervention measured by the attrition rate
Timeframe: through study completion, approximately 17 months
Trial safety is measured by the frequency and severity of recorded adverse events related to the trial
Timeframe: through study completion, approximately 17 months
Feasibility of assessments is measured by the number of completed assessments
Timeframe: Through study completion, approximately 17 months