Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia (NCT07325175) | Clinical Trial Compass
RecruitingNot Applicable
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
United States75 participantsStarted 2024-01-01
Plain-language summary
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are:
How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)?
Participants will:
* Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task.
* Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.
Who can participate
Age range
6 Years – 21 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* For dystonia subjects:
* Dx of dystonia (with and without DBS)
* willingness and ability to complete study protocols.
* For Typically Developing Controls:
* normal developmental milestones
* absence of any neuropsychiatric disorder
* no significant medical condition.
Exclusion Criteria:
* history of epilepsy
* presence of implanted medical devices (except DBS in dystonia subjects)
* lack of cognitive or physical ability to complete study protocol.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is measuring something called 'motor network aperiodic activity' over time — can you explain in simple terms what that means and why tracking it might help predict how well deep brain stimulation works for my child's dystonia?
2Since this trial is listed as Phase NA, it sounds like it may be more of an observational or measurement study rather than a treatment trial — can you clarify whether participating would actually change my child's treatment plan, or is it mainly about collecting data to understand the condition better?
3What would be involved for my child in terms of visits, tests, or procedures if we were to discuss enrolling in this study, and how might those demands fit into our current schedule of care?
4Before considering this trial, should we first make sure my child has explored or tried standard treatment options for pediatric dystonia, and how does participating in a study like this fit alongside those options?
5This study is focused on children with dystonia — given my child's specific type and severity of dystonia, is this the kind of research that my doctor thinks could be relevant to their situation, or are there other studies or treatments that might be a higher priority to discuss first?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Longitudinal change in Motor Network Aperiodic Activity
Timeframe: -Baseline -Through study completion, an average of 2 years
Trial details
NCT IDNCT07325175
SponsorChildren's Hospital Medical Center, Cincinnati