The Effectiveness of a Herbal Supplement in Osteoarthritis. (NCT07324746) | Clinical Trial Compass
RecruitingNot Applicable
The Effectiveness of a Herbal Supplement in Osteoarthritis.
United Kingdom30 participantsStarted 2025-12-05
Plain-language summary
This study aims to evaluate the effectiveness and safety of a combined herbal supplement containing Boswellia serrata, Curcuma longa, and Vitis vinifera in adults with clinically diagnosed knee or hip osteoarthritis.
The primary objective is to determine whether the supplement improves osteoarthritis-related symptoms.
The supplement will be compared with a placebo.
Participants will:
* take the supplement and placebo for 4 weeks each, one at a time;
* complete validated questionnaires (6 times online)
* perform three performance-based physical tests (6 times online)
* provide a urine sample
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged ≥ 18
* Diagnosis of osteoarthritis in knee or hip
* Numerical Rating Scale (NRS) ≥ 4 during the most painful movement in the last 24 hours
* Lequesne's Functional Index (LFI) score ≥ 7
* Ambulant patient
Exclusion Criteria:
* Pregnant and breastfeeding
* Autoimmune disease such as rheumatoid arthritis, gout, lupus
* Joint trauma, joint injury, joint infection, meniscus tear, complete loss of articular cartilage
* Expectation of surgery
* History of the viscous or corticosteroids injections into affected joints or oral corticosteroids within last 12 months
* Allergy to one of the intervention's ingredients or NSAIDs
* Peptic ulceration and upper gastrointestinal haemorrhage
* High alcohol intake, inability to abstain from alcohol, substance abuse, history of addiction
* Tumor, cancer
* Abnormal renal or/and hepatic functions or altered blood chemistry
* Use of concomitant medication able to interfere with the interventions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) score
Timeframe: Change from the start of the intervention to Week 4 of supplementation
2
Change in Numeric Rating Scale (NRS) score
Timeframe: Change from the start of the intervention to Week 4 of supplementation
3
Change in Intermittent and Constant Osteoarthritis Pain knee/hip (ICOAP) score
Timeframe: Change from the start of the intervention to Week 4 of supplementation
4
Change in EuroQol 5-Dimension 5-Level (EQ-5D-5L) score
Timeframe: Change from the start of the intervention to Week 4 of supplementation
5
Change in urinary C-terminal telopeptide of type II collagen (uCTX-II) levels
Timeframe: Change from the start of the intervention to Week 4 of supplementation