CompletedNot Applicable

Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients

China6,475 participantsStarted 2020-04-01

Plain-language summary

Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear. This study aimed to evaluate the frailty-stratified association between preoperative LMR and POD in older surgical patients.

Who can participate

Age range65 Years

SexALL

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Inclusion Criteria: * Aged ≥65 years; * Underwent elective noncardiac, nonneurosurgical procedures; * Completed the preoperative health and functional status questionnaire. Exclusion Criteria: * Severe dementia, language disorders, significant hearing or visual impairments, or coma; * Cognitive function below the Mini-Mental State Examination thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher); * Surgery performed under local anesthesia or monitored anesthesia care; * Missing lymphocyte or monocyte count data; * Missing postoperative delirium assessment; * Incomplete preoperative FRAIL scale evaluation; * Missing data for more than 20% of covariates.

What they're measuring

The primary outcome was the occurrence of postoperative delirium (POD).

Timeframe: POD assessment was performed twice daily for up to seven consecutive postoperative days or until hospital discharge, whichever occurred first.

Trial details

NCT IDNCT07322744

SponsorChinese PLA General Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-04-30

View on ClinicalTrials.gov More Postoperative Delirium (POD) trials