Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older S… (NCT07322744) | Clinical Trial Compass
CompletedNot Applicable
Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients
China6,475 participantsStarted 2020-04-01
Plain-language summary
Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear. This study aimed to evaluate the frailty-stratified association between preoperative LMR and POD in older surgical patients.
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged ≥65 years;
* Underwent elective noncardiac, nonneurosurgical procedures;
* Completed the preoperative health and functional status questionnaire.
Exclusion Criteria:
* Severe dementia, language disorders, significant hearing or visual impairments, or coma;
* Cognitive function below the Mini-Mental State Examination thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher);
* Surgery performed under local anesthesia or monitored anesthesia care;
* Missing lymphocyte or monocyte count data;
* Missing postoperative delirium assessment;
* Incomplete preoperative FRAIL scale evaluation;
* Missing data for more than 20% of covariates.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The primary outcome was the occurrence of postoperative delirium (POD).
Timeframe: POD assessment was performed twice daily for up to seven consecutive postoperative days or until hospital discharge, whichever occurred first.