Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine (NCT07322419) | Clinical Trial Compass
RecruitingPhase 4
Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine
Egypt200 participantsStarted 2026-01-01
Plain-language summary
Echocardiography will be used to measure cardiac output and calculate other important hemodynamic variables in healthy patients with full-term singleton pregnancy during cesarean delivery under conventional spinal anesthesia using 2 different vasopressor drugs: norepinephrine in 1 group versus ephedrine in another group.
Who can participate
Age range
19 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* American Society of Anesthesiologists physical status II.
* Singleton, full term pregnancy.
* Scheduled cesarean delivery under spinal anesthesia.
Exclusion Criteria:
* Height \<150 or \>180 cm.
* Weight \<60 or \>110 kg.
* Body mass index (BMI) \<18.5 or ≥35 kg/m².
* Women presenting in labor.
* Any contraindication to spinal anesthesia: increased intracranial pressure, coagulopathy, or local skin infection.
* Chronic or pregnancy-induced hypertension.
* Baseline systolic blood pressure \>140 mm Hg.
* Hemoglobin \<10 g/dl.
* Diabetes mellitus, cardiovascular, cerebrovascular, or renal disease.
* Polyhydramnios or known significant fetal abnormalities.
* Current administration of vasoactive drugs such as: beta blockers, salbutamol, or thyroxin.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Difference between the 2 groups in cardiac output at 10 minutes after intrathecal injection
Timeframe: From the start of spinal anesthesia until delivery