CompletedNot Applicable

Bedside PEEP Selection in by Electrical Impedence Tomography During Mechanical Ventilation in Children

Italy14 participantsStarted 2024-12-01

Plain-language summary

This prospective study evaluates the feasibility and safety of using Electrical Impedance Tomography (EIT) to guide PEEP selection in mechanically ventilated infants and toddlers under 3 years of age. This population is challenging for its variety and anatomophysiologic peculiarity. A decremental PEEP trial using 1 cmH₂O steps following a recruitment maneuver at 35 cmH₂O was compared between EIT and other best PEEP assessment protocols.

Who can participate

Age range0 Years – 3 Years

SexALL

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Inclusion criteria

✓. oxygenation Index (OI = mean airway pressure multiplied by FiO₂ divided by PaO₂) greater than 4; and/or
✓. an Oxygen Saturation Index (OSI = mean airway pressure multiplied by FiO₂ divided by SpO₂) greater than 5; or
✓. altered respiratory mechanics - defined as reduced respiratory system compliance normalized to body weight (Crs/kg) below 0.7 mL/cmH₂O/kg.

What they're measuring

Feasibility (% of patients that complete the EIT-guided PEEP trial)

Timeframe: 20 weeks

Trial details

NCT IDNCT07319624

SponsorPapa Giovanni XXIII Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04-30

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