Advanced PRF vs PRF for Gap Filling in Immediate Implants (NCT07319494) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Advanced PRF vs PRF for Gap Filling in Immediate Implants
Egypt16 participantsStarted 2025-06-25
Plain-language summary
Study type: Clinical Trial
Goal:
The goal of this clinical trial is to learn if Advanced Platelet-Rich Fibrin (A-PRF) versus traditional Platelet-Rich Fibrin (PRF) can improve bone healing and soft tissue outcomes in patients undergoing immediate dental implant placement.
Main questions it aims to answer:
Does A-PRF provide greater buccal bone preservation compared to PRF after immediate implant placement?
Does A-PRF improve soft tissue healing and reduce postoperative complications compared to PRF?
Comparison group:
Researchers will compare A-PRF to PRF as a gap-filling material in immediate implants to see if A-PRF results in better bone and soft tissue outcomes.
Participants will:
Undergo tooth extraction followed by immediate implant placement
Receive either A-PRF or PRF as the gap-filling material in the implant site
Have CBCT scans at baseline and 6 months to measure bone thickness
Have clinical assessments of soft tissue healing and implant stability
Attend follow-up visits at 1 week, 1 month, 3 months, and 6 months post-surgery
Who can participate
Age range
20 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* The selected patients has a badly decayed mandibular posterior teeth which are indicated for extraction due to dental causes (periapical abscess, trauma or caries) not periodontal as diagnosed by periapical x-ray.
* Healthy patients who are classified according to the American Society of Anesthesiologists (ASA)(2022) physical status classification as class I.
* Patient age ≥ 20 years old.
* Surgical site with sufficient for implant placement.
* Sufficient interocclusal space for prosthesis.
* Good oral hygiene.
* Patients have thick biotype.
* Patients have socket class I.
Exclusion Criteria:
* Active periodontal diseases and periapical lesions not chronic infections.
* Patients have parafunctional
* History of alcohol or drug dependency, psychological factor that might affect the surgical or prosthodontic treatment.
* Smoking.
* Pregnant patients.
* Patients who are not willing to complete the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.