Creation of a Digital Twin for Predicting the Progression of Patients With Chronic Thoracic Aorti… (NCT07315178) | Clinical Trial Compass
RecruitingNot Applicable
Creation of a Digital Twin for Predicting the Progression of Patients With Chronic Thoracic Aortic Dissection
France400 participantsStarted 2025-11-25
Plain-language summary
Aortic dissection causes a tear in the inner layers of the aorta, leading to the formation of a true and false lumen.
There are two types of dissection: type A, which affects the ascending aorta, and type B, which affects the descending aorta. Type A aortic dissection is almost always a surgical emergency and involves replacing the ascending aorta with a prosthesis. After this type of dissection, a residual dissection remains in the descending aorta, known as residual type B dissection, which becomes chronic. This requires increased monitoring by MRI or CT scan, which are currently not effective enough to predict the development of an aneurysm that could lead to aortic rupture requiring surgical intervention. Other factors such as blood flow, the forces and mechanisms regulating blood circulation, the mechanics and histology of the aorta, and blood markers could provide a more reliable prediction of the development of an aneurysm. The creation of a digital twin model incorporating all these factors should enable better patient management.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Person who has given written consent
* Age \> 18 years
* Patient with type A aortic dissection with surgical indication for replacement
* Patient with chronic type B aortic dissection, monitored and managed medically, not operated on
Exclusion Criteria:
* Persons not affiliated with or not covered by a social security scheme
* Persons subject to legal protection measures (guardianship)
* Persons subject to judicial protection measures
* Pregnant women, women in labour or breastfeeding
* Adults who are incapacitated or unable to give their consent
* Contraindications to MRI: claustrophobia, non-MRI-compatible metal implants, suspected metal foreign body
* Severe renal failure (clearance \<30ml/min according to Cockroft due to gadolinium injection)
* Uncontrolled asthma
* Patients with acute type A aortic dissection who died during or in the post-operative period following surgery to repair the dissection
* Patients with a known allergy to gadolinium-based contrast agents
* Patients treated for type B aortic dissection who underwent surgery
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.