CompletedPhase 4

Enhanced Recovery After Surgery-Based Multimodal Preemptive Analgesia for Perioperative Management in Transarterial Chemoembolization of Intermediate-to-Advanced Hepatocellular Carcinoma

China129 participantsStarted 2024-08-01

Plain-language summary

To evaluate the effectiveness of the combination of hydrochloride hydromorphone and flurbiprofen ester for post-TACE intravenous patient-controlled intravenous analgesia (PCIA).

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Pathologically or clinically diagnosed with hepatocellular carcinoma according to the "Guidelines for Diagnosis and Treatment of Primary Liver Cancer" issued by the National Health Commission of China in 2024;
✓. staged as China Liver Cancer Stage II-III1 or 2022 Barcelona Clinic Liver Cancer stage B-C14;
✓. liver function classified as Child-Pugh grade A or B;
✓. ECOG PS score 0-215;
✓. meeting the following hematological criteria: white blood cell count ≥3×10⁹/L, platelet count ≥50×10⁹/L, hemoglobin ≥80 g/L, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) ≤twice the upper limit of normal (ULN), serum creatinine ≤1.5×ULN, INR \<1.5 or prothrombin time \<ULN + 4 s, albumin (ALB) ≥30 g/L, total bilirubin \<34 mmol/L.

Exclusion criteria

✕. History of iodine contrast allergy;
✕. severe psychological or psychiatric disorders;
✕. history of long-term analgesic medication use;
✕. severe cardiopulmonary disease;
✕. severe uncontrolled infection;
✕. incomplete medical records.

What they're measuring

Perioperative numerical pain rating scale (NRS) score

Timeframe: From the start of the operation to 24 hours after the operation

Trial details

NCT IDNCT07315022

SponsorFirst Affiliated Hospital, Sun Yat-Sen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-30

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