Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Co… (NCT07314853) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial
Italy176 participantsStarted 2026-02
Plain-language summary
The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients undergoing major cancer surgery. The main questions it aims to answer are:
* Does artificial intelligence-guided fluid therapy reduce hypotensive events during surgery?
* Does this approach improve recovery and reduce complications after major cancer surgery?
Researchers will compare artificial intelligence-guided fluid therapy with standard fluid management to see if the artificial intelligence-guided approach provides better support during surgery.
Participants will:
* Undergo major cancer surgery under general anesthesia
* Receive either artificial intelligence-guided fluid management or standard fluid management during surgery
* Be monitored during and after surgery as part of routine clinical care
* Be followed after surgery to assess recovery and possible complications
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* American Society of Anesthesiologists (ASA) Physical Status II-IV
* Undergoing major abdominal oncologic surgery (open or laparoscopic) with an expected duration \>2 hours
* Planned invasive arterial pressure monitoring
* Ability to understand and sign informed consent
Exclusion Criteria:
* Significant arrhythmias (e.g., persistent atrial fibrillation)
* Severe aortic stenosis
* Emergency surgery
* Sepsis
* End-stage renal disease on dialysis
* Pregnancy
* Impossibility to cannulate the radial artery
* Refusal to participate or refusal of data processing consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Intraoperative Hypotension Burden
Timeframe: From induction of anesthesia to the end of surgery