By InvitationNot Applicable

Mode of Ventilation During Critical Illness at Multiple Centers

United States4,785 participantsStarted 2026-05-01

Plain-language summary

The goal of this clinical trial is to learn whether the choice of ventilator mode for patients on breathing machines in the intensive care unit affects their survival and recovery. To do this, researchers will assign the entire participating intensive care unit to one of the three available ventilator modes, alternating which mode is assigned in random sequence every 2 months. The main question it aims to answer is: Does the choice between volume control, pressure control, and adaptive pressure control affect the number of days that patients are alive and free of the breathing machine?

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient is receiving mechanical ventilation through an endotracheal tube or tracheostomy * Patient is physically located in a participating adult ICU Exclusion Criteria: * Patient is known to be less than 18 years old * Patient is known to be a prisoner * Patient is known to have been receiving invasive mechanical ventilation at place of residence prior to hospital admission * Patient is receiving extracorporeal membrane oxygenation at the time when inclusion criteria are first met

What they're measuring

Ventilator-free days in the first 28 days

Timeframe: From enrollment to 28 days after enrollment

Trial details

NCT IDNCT07313956

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-01

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