Not Yet RecruitingNot Applicable

Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage

233 participantsStarted 2026-06-01

Plain-language summary

Rationale: Aneurysms of different types are known to be associated. In literature, concurrence of intracranial- and aortic aneurysms is described. Screening for aortic aneurysms (AA) in patients with intracranial aneurysms (IA) or aneurysmal subarachnoid haemorrhage (aSAH) could be cost-effective and of significant importance to decrease morbidity and mortality. The available literature on the association between the two types of aneurysms is sparse and in general of poor methodological quality. This protocol presents a study to more adequately evaluate the association between IA and AA. Objective: To investigate the occurrence of abdominal aortic aneurysms (AAA) in patients who experienced aSAH. Study design: This single cohort prospective study will include patients who experienced aSAH. The study participants will receive an abdominal ultrasound of the aorta to detect an AAA. Study population: aSAH patients from a prospective cohort trial in the Netherlands. Main study parameters/endpoints: The primary outcome, which will be investigated in the here above described study population, is the number of AAA detected on abdominal ultrasound. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Patients will not receive an intervention, but only a diagnostic imaging without radiation. The burden associated with this study are considered minimal and the risks negligible. An abdominal ultrasound is a non-invasive diagnostic method with no risks for the participant. The only possible existing burden to the participant is travel and appointment time with a risk of detecting an abdominal aortic aneurysm or other (occult) intra-abdominal pathologies. When an aneurysm, sub-aneurysm or other intra-abdominal pathology is detected, surveillance or treatment according to standard of care and guidelines will follow.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria: * Patient is a study subject of the trial: Study on Prognosis of Acutely RupTured Aneurysms (SPARTA)(12) * Inclusion at least one year after aSAH * Written informed consent By being a study subject of the SPARTA trial, the following criteria are applicable: * Confirmed diagnosis of SAH on CT-scan or lumbar puncture (in the presence of a negative CT-scan) * IA related SAH as confirmed with radiological imaging * Age 18 years or older at presentation * Written informed consent for the SPARTA-trial Exclusion Criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: * Patient is not a study subject of the SPARTA trial * Patient has Loeys-Dietz-, Marfan- or Ehlers-Danlos syndrome

What they're measuring

Occurrence of AAA

Timeframe: 1 year

Trial details

NCT IDNCT07312565

SponsorLeiden University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-01

Contact for this trial

Alexander Hamming, MD

+31655322609 a.hamming@haaglandenmc.nl