Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID? (NCT07312409) | Clinical Trial Compass
RecruitingNot Applicable
Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?
Canada30 participantsStarted 2026-06-01
Plain-language summary
Millions have developed Long COVID (LC), and recent findings show an association between taurine deficiency (an amino acid) and symptoms in LC. Cost-effective and accessible interventions are needed to improve welfare and reduce healthcare costs. We will investigate the efficacy of 12-weeks of taurine supplementation (self-administered), on vascular function and the cardio/cerebrovascular responses to upright posture. We will measure resting vascular function with an EndoPAT device, resting heart rate variability, and the blood pressure, heart rate, and brain blood flow responses to 5 minutes of head-up tilt before and after weeks of taurine supplementation in LC. We hypothesize that the 12 weeks of supplementation will improve both resting vascular function and the responses to upright tilt. In turn, we hypothesize that symptoms will also improve (as measured by questionnaires).
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants will have had symptoms of Long COVID post-infection for at least 3 months
Exclusion Criteria:
* Inability to undergo tilt table testing for 5 minutes
* Inability to transport selves to York University from their homes
* Inability to speak English, or provide a translator
* Blood clotting disorders
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at taurine supplementation for Long COVID — is taurine something you'd consider safe for me to discuss trying, and are there any interactions with my current medications or conditions I should be aware of?
2The trial is specifically measuring orthostatic responses, which relates to symptoms like dizziness or lightheadedness when standing up — do my current Long COVID symptoms match what this study seems to be targeting, and would it be worth bringing up with the research team?
3Since this is listed as Phase NA, which often means it's an early or exploratory study, what does that tell us about how much is already known about whether taurine actually helps vascular problems in Long COVID?
4The trial is measuring vascular function alongside orthostatic responses — can you help me understand whether my Long COVID symptoms might involve vascular issues, and how that affects whether this study could be relevant to me?
5Are there any standard treatments or other established approaches for Long COVID-related vascular or orthostatic problems that we should try first before I consider enrolling in a research study like this?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.