Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs… (NCT07311759) | Clinical Trial Compass
Active — Not RecruitingPhase 3
Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs 0.1% Topical Mometasone Furoate With 2% Miconazole Nitrate Cream in the Treatment of Chronic Paronychia: An Intraindividual Randomized Controlled Trial.
Egypt21 participantsStarted 2024-08-17
Plain-language summary
Our objective is to compare the efficacy and safety of intralesional corticosteroids + fluconazole solution to corticosteroid with an antifungal topical preparation, in the management of chronic paronychia.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients with chronic paronychia affecting ≥ 2 fingernails in the dominant hand.
. Patients not receiving any relevant systemic treatment for at least 4 weeks before initiation of our study
. Patients not receiving any relevant topical treatment for at least 2 weeks before initiation of our study
Exclusion criteria
. Patient with peripheral vascular disease or Raynaud's phenomenon
. Pregnant and lactating females
. Patients with autoimmune diseases e.g., connective tissue diseases, psoriasis, reactive arthritis, and pemphigus.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Comparison between the chronic paronychia severity index scale before and after treatment in each group
Timeframe: 4 months
2
Comparison of the change in chronic paronychia severity index scale between both groups
Timeframe: 4 months
3
Comparison of percentage of patients who achieved complete response (chronic paronychia severity index scale =0) between both groups.
. Patients with solid or hematological malignancies.
. Patients on systemic drugs that are known to cause chronic paronychia e.g. retinoids.
. Patients with any visible focus of infection at the injection site or in the vicinity, including patients with superimposed attack of acute paronychia.