CompletedNot Applicable

Impact of Arterial Partial Pressure of Oxygen on Anastomotic Leakage After Esophagectomy

China2,083 participantsStarted 2021-01-01

Plain-language summary

This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. We conducted a retrospective analysis of cases from our center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * The inclusion criteria required patients diagnosed with esophageal carcinoma or benign esophageal tumors and requiring surgical resection of the lesion with subsequent esophageal reconstruction. Additionally, patients must have had at least one postoperative arterial blood gas analysis and routinely undergone either endoscopy, CT scan, or esophagram for postoperative evaluation of the anastomosis. Exclusion Criteria: * We excluded patients who did not require esophageal reconstruction, those undergoing esophageal replacement with colon, and those with incomplete data.

What they're measuring

Esophageal Anastomotic Leakage Rate

Timeframe: From the date of surgery to 30 days postoperatively

Trial details

NCT IDNCT07309991

SponsorSun Yat-sen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-01

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