Clinical ,Microbiological and Compliance Outcomes of AI-based Toothbrushes in Plaque Induced Ging… (NCT07308522) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Clinical ,Microbiological and Compliance Outcomes of AI-based Toothbrushes in Plaque Induced Gingivitis
Iraq33 participantsStarted 2026-01-01
Plain-language summary
Severe periodontitis is widespread and begins with reversible gingivitis, driven by poor oral hygiene and a dysbiotic microbiome. Daily toothbrushing is the simplest prevention, but patients still leave plaque. Electric brushes remove more plaque and reduce gingivitis better than manual ones, and users show better periodontal status. App-connected smart brushes and apps aim to improve adherence. Trials increased plaque reduction and brushing time versus manual brushing, but app layers have not clearly beaten standard power brushes, and microbiological outcomes are rarely reported. Xiaomi's AI-based sonic T501 adds pressure sensing, personalised coaching and coverage tracking, whereas the T302 is a simpler non-connected sonic brush. Streptococcus sanguinis is a health-associated early coloniser; its qPCR-measured relative abundance marks a healthy supragingival profile. It is still unclear whether AI guidance adds extra benefit beyond a standard electric brush in adult gingivitis.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants should be systemically healthy
* 18 years old, with the presence of ≥ 20 teeth
* Diagnosed with generalized plaque-induced gingivitis having \>30% bleeding sites, with probing depths ≤3 mm and intact periodontium
* Participants with at least secondary school education, who are able to read and understand basic English to follow the app-based toothbrush instructions
Exclusion Criteria:
* Participants who using antibiotics or anti-inflammatory medication throughout the investigation or during the previous 3 months prior to the study.
* Drug-induced gingival enlargement (phenytoin, cyclosporine, calciumchannel blockers).
* Individuals with periodontitis and healthy periodontium.
* Mouth breathers .
* Individuals with severe dental crowding or malalignment that prevents proper toothbrushing.
* Individuals with heavy calculus.
* Individuals who smoke or alcoholism.
* Pregnant, breastfeeding women or those using contraceptive tablets.
* Individuals with orthodontic devices or removable dentures
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Plaque index
Timeframe: This index will be recorded at baseline, after 2 weeks, and 2 months after enrollment