Investigation of the Effects of Interlaminar Epidural Steroid Injection on Upper Extremity Propri… (NCT07307846) | Clinical Trial Compass
RecruitingNot Applicable
Investigation of the Effects of Interlaminar Epidural Steroid Injection on Upper Extremity Proprioception in Patients With Chronic Cervical Radiculopathy
Turkey (Türkiye)46 participantsStarted 2026-01-05
Plain-language summary
Cervical radiculopathy is a common condition caused by irritation or compression of cervical nerve roots, often leading to unilateral neuropathic pain and functional impairment. Proprioceptive deficits in the upper extremity have been demonstrated in various cervical spine disorders; however, the effect of interlaminar epidural steroid injection (ILESI) on upper extremity proprioception in patients with chronic cervical radiculopathy has not been previously examined.
This prospective interventional study aims to evaluate changes in upper extremity proprioception following unilateral ILESI in patients with cervical disc herniation-related chronic radiculopathy. A secondary aim is to investigate the relationship between proprioceptive changes and clinical outcomes such as pain, neuropathic pain, disability, grip strength, and quality of life.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Participants must meet all of the following:
* Female or male, 18-65 years of age
* Presence of unilateral cervical radicular pain lasting at least 3 months
* MRI of the cervical spine within the last 12 months demonstrating at least one cervical disc herniation consistent with the patient's symptoms
* Diagnosed with chronic cervical radiculopathy based on history, physical examination, and clinical evaluation
* Ability to read and write (literacy)
* Willingness to participate and ability to provide written informed consent
Exclusion Criteria:
Participants will be excluded for any of the following:
* Cervical physical therapy or cervical spinal injection performed within the past 6 months
* Symptoms or diagnosis of upper extremity entrapment neuropathy
* Documented vitamin B12 deficiency or vitamin D deficiency on laboratory results within the past year
* History of cervical spine surgery or significant cervical trauma
* Bilateral cervical radicular pain
* Cervical spinal stenosis
* History of upper extremity surgery or significant upper extremity trauma
* Cognitive impairment, major psychiatric disorder, intellectual disability, or history of significant neurological disease
* Diagnosis of polyneuropathy
* Diagnosis of Diabetes Mellitus
* Diagnosis of fibromyalgia
* Current use of medications that may impair proprioception or have sedative effects (e.g., gabapentinoids, antidepressants, muscle relaxants)
* Active local or systemic infection
* Coagulo…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Upper Extremity Proprioception Error (PRO-Reach)
Timeframe: Baseline (T0), 3 weeks after ILESI (T1), and 3 months after ILESI (T2)