CompletedNot Applicable

Intramuscular vs Rectal Progesterone in Preventing Preterm Labour After Cervical Cerclage

Pakistan820 participantsStarted 2021-10-26

Plain-language summary

Preterm labour is a major cause of neonatal morbidity and mortality worldwide. Progesterone supplementation is known to help reduce the risk of preterm birth in high-risk women. This randomized controlled trial compared the effectiveness of intramuscular progesterone and rectal progesterone in preventing preterm labour among pregnant women who had undergone cervical cerclage. The study aimed to determine which route of progesterone administration provides better pregnancy prolongation and improved neonatal outcomes.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Pregnant women aged 18-45 years Singleton pregnancy Gestational age between 16 and 24 weeks at enrollment Diagnosed with cervical insufficiency and scheduled for or recently undergone cervical cerclage Willing to receive progesterone therapy and provide written informed consent Exclusion Criteria: Multiple pregnancy Known fetal anomalies Severe maternal comorbidities (e.g., hypertension, diabetes, cardiac disease) History of allergy or hypersensitivity to progesterone or related compounds Contraindications to progesterone use Women who declined to participate or were non-compliant with follow-upInclusion Criteria: \- Exclusion Criteria: \-

What they're measuring

Frequency of Preterm Birth (<37 Weeks)

Timeframe: 16-36 weeks until delivery

Trial details

NCT IDNCT07307092

SponsorHina Mukhtar

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-25

View on ClinicalTrials.gov More Preterm Labour trials