CompletedNot Applicable

Non-Invasive High-Frequency Oscillatory Ventilation vs Conventional Ventilation for Preterm Neonates.

Pakistan100 participantsStarted 2025-06-01

Plain-language summary

Given the high burden of respiratory distress syndrome (RDS) and its complications in resource-constrained settings, identifying effective, low-risk interventions is imperative. The study aimed to assess the improvement in oxygenation and ventilation parameters initiating non-invasive high-frequency oscillatory ventilation (nHFOV) or conventional mechanical ventilation (CMV) and to compare the incidence of air leaks, sepsis, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), prolonged hospital stays, and short-term survival rates.

Who can participate

Age range1 Day – 28 Days

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Neonates of any gender * Gestational age between 26 and 36 weeks * Diagnosed with RDS. * Failed to respond to nCPAP treatment Exclusion Criteria: * Major congenital anomalies like congenital diaphragmatic hernia, dysmorphism and congenital heart diseases * Early onset sepsis at the time of enrollment

What they're measuring

Improvement in ventilation parameter

Timeframe: 24 hours

Trial details

NCT IDNCT07307079

SponsorMuhammad Aamir Latif

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-30

View on ClinicalTrials.gov More Respiratory Distress Syndrome trials