Not Yet RecruitingNot Applicable

Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic .

110 participantsStarted 2025-12-30

Plain-language summary

1. To evaluate the eﬃcacy of a standardized multimodal Opioid Sparing (OS) protocol versus conventional opioid-based analgesia in reducing acute postoperative 2. To quantify opioid consumption reduction achievable through OS strategies 3. To assess the impact of OS on hemodynamic parameters during critical surgical phases 4. To compare recovery metrics (PONV, bowel function, ambulation) 5. To evaluate the safety proﬁle of OS anesthesia

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 to 60 years scheduled for elective laparoscopic cholecystectomy. Elective must be included in title. * ASA (American Society of Anesthesiologists) physical status I or II. * Body Mass Index (BMI) \< 35 kg/m². Exclusion Criteria: * Chronic opioid use (\>30 MME/day for \>3 months). * Contraindications to study medications (e.g., severe hepatic impairment; allergy/contraindication to lidocaine, dexmedetomidine, ketamine, fentanyl, or NSAIDs). * Renal dysfunction (eGFR \<60 mL/min/1.73 m²). * Significant cardiac conduction abnormalities. * Pregnancy or lactation. * Emergency surgery or conversion to open cholecystectomy

What they're measuring

Pain intensity at rest postoperatively (Visual Analog Scale, VAS, 0-10)

Timeframe: 48 hours post operative

Trial details

NCT IDNCT07306910

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-30

Contact for this trial

Ola Mahmoud Wahba Gnedy, Assistant Prof.

01151121981 ola.genadi@med.aun.edu.eg

View on ClinicalTrials.gov More Opioid-Free Anesthesia trials