Evaluation of Toothbrush Bristles (NCT07306026) | Clinical Trial Compass
RecruitingNot Applicable
Evaluation of Toothbrush Bristles
United States70 participantsStarted 2025-10-21
Plain-language summary
The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles.
The main questions it aims to answer are the effects of two different bristle types on:
* how much plaque is on the teeth
* how deep the space is between gums and teeth
* how much gum and bone are attached to the teeth
* whether the gums bleed when checked
* if the gums get scratched or irritated
Researchers will compare toothbrushes with tapered bristles to those with regular round bristles.
Participants will be randomly assigned toothbrush A or B to use at home during the study.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Must have read, understood and signed an informed consent prior to being entered into the study.
* Must be 18 to 70 years of age, male or female.
* Have at least 20 natural or restored teeth, not including implants.
* Must have average Plaque Index of greater than 2 at screening.
* Must have more than 20% of pockets with bleeding on probing at screening.
* Agree not to have a dental prophylaxis or any other elective, non-emergency dental procedures any time during the study.
* Agree to refrain from regular oral hygiene regimen for 24 hours and eating for 4 hours before the appointment in the study.
* Agree to abstain from the use of any dental products other than those provided in the study.
* Agree to comply with the conditions and schedule of the study.
Exclusion Criteria:
* Physical limitations or restrictions that might preclude normal tooth brushing.
* Evidence of gross oral pathology
* Periodontal probing pocket depths (PPD) ≥ 5mm.
* Evidence of major soft tissue lesions or trauma at the baseline visit as determined by the examiner.
* Chronic disease with concomitant oral manifestations
* Subjects who are currently undergoing, or require, extensive dental work, orthodontic treatment or periodontal surgery, or orthodontic treatment in the preceding 3 months
* Currently using bleaching trays
* Eating disorders
* Recent history of substance abuse
* Smoking \>10 cigarettes/day
* Participation in other clinical studies within 14 days of screening
* P…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Rustogi Modified Navy Plaque Index
Timeframe: Baseline, Week 2 and Week 4
Trial details
NCT IDNCT07306026
SponsorState University of New York at Buffalo
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2026-06-30
Contact for this trial
Senior Clinical Research Coordinator, Bachelor of Science