CompletedPhase 3

The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction

China52 participantsStarted 2025-12-29

Plain-language summary

This study will enroll 40 subjects aged 18 years or older scheduled for elective surgery under general anesthesia with endotracheal intubation. Basic medical history information will be collected. Subjects will be divided into two groups of 20 each: a remimazolam group and a propofol group. The study period will span from one day before surgery to one day after surgery. The study will assess middle cerebral artery cerebral blood flow following general anesthesia induction and postoperative anesthesia recovery.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patients who have signed the informed consent form and are willing to comply with the study protoco * Age greater than 18 years * ASA physical status classification I to II * Scheduled for elective surgery * Undergoing general anesthesia with endotracheal intubation * No history of cerebrovascular disease, carotid artery stenosis, or traumatic brain injury. Exclusion Criteria: * History of intracranial lesions, carotid artery stenosis, or traumatic brain injury * Allergy or contraindications to remimazolam or propofol.

What they're measuring

Peak systolic blood flow velocity (PS)

Timeframe: 1, 3, 5, and 10 minutes after endotracheal intubation.

Trial details

NCT IDNCT07303985

SponsorJun Zhang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02-28

View on ClinicalTrials.gov More Cerebral Blood Flow trials