CompletedNot Applicable

The Effectiveness of Pain Neuroscience Education for Patients With Carpal Tunnel Syndrome

Turkey (Türkiye)48 participantsStarted 2025-12-29

Plain-language summary

The goal of this clinical trial is to investigate the effects of Pain Neuroscience Education applied in the treatment of mild and moderate carpal tunnel syndrome (CTS). The main question it aims to answer is: Does PNE have a therapeutic effect on carpal tunnel syndrome in clinical and ultrasonographic terms? Researchers will compare whether PNE creates a synergistic effect alongside home based exercise programs and splint application in mild to moderate CTS, and will objectively demonstrate potential benefits such as relief from pain and numbness.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Being 18 years of age or older * Having a diagnosis of mild or moderate CTS confirmed by ENMG * Having complaints of pain and numbness in the first three fingers of the hand for at least 3 months Exclusion Criteria: * Presence of severe CTS findings on electrophysiological examination * Presence of metabolic diseases such as uncontrolled diabetes and hypothyroidism * Presence of inflammatory rheumatic disease (e.g., rheumatoid arthritis) * Presence of other neuromuscular diseases affecting the hand and wrist (Polyneuropathy, Cervical radiculopathy, peripheral nerve damage, Brachial plexus damage, other entrapment neuropathies, etc.) * History of hand and wrist trauma * History of neck and wrist surgery * History of steroid injection into the carpal tunnel within the last 3 months * History of physical therapy application to wrist within the last 3 months * Deformity preventing the use of a splint on the wrist * Previous participation in a program for the psychological management of chronic pain * Cognitive dysfunction preventing cooperation with tests

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Boston Carpal Tunnel Questionnaire - Symptom Severity Scale

Timeframe: Baseline, in the 3rd week and in the 6th week

Boston Carpal Tunnel Questionnaire - Functional Status Scale

Timeframe: Baseline, in the 3rd week and in the 6th week

Numerical Rating Scale

Timeframe: Baseline, in the 3rd week and in the 6th week

6-item carpal tunnel syndrome symptom scale (CTS-6)

Timeframe: Baseline, in the 3rd week and in the 6th week

Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)

Timeframe: Baseline, in the 3rd week and in the 6th week

Trial details

NCT IDNCT07302282

SponsorKaramanoğlu Mehmetbey University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-31

View on ClinicalTrials.gov More Carpal Tunnel Syndrome (CTS) trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Boston Carpal Tunnel Questionnaire - Symptom Severity Scale

Timeframe: Baseline, in the 3rd week and in the 6th week

Boston Carpal Tunnel Questionnaire - Functional Status Scale

Timeframe: Baseline, in the 3rd week and in the 6th week

Numerical Rating Scale

Timeframe: Baseline, in the 3rd week and in the 6th week

6-item carpal tunnel syndrome symptom scale (CTS-6)

Timeframe: Baseline, in the 3rd week and in the 6th week

Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)

Timeframe: Baseline, in the 3rd week and in the 6th week