RecruitingPhase 1/2

Low-Tech Treatments for Obstructive Sleep Apnea

United States60 participantsStarted 2026-01-29

Plain-language summary

The overall purpose of this study is to compare changes in sleep outcomes in people with obstructive sleep apnea (OSA) depending on their participation in one of two behavioral interventions; both involve drinking water and breathing. A second purpose is to compare outcomes between people who have sustained a traumatic brain injury (TBI) and those with no history of TBI. The main questions it aims to answer are whether sleep quality improves after 3-months of high-resistance versus low-resistance exercises, and whether people have different outcomes depending on their history of TBI.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * New diagnosis of OSA (AHI, ≥ 5) or failure of first-line OSA treatment; * Willingness to forego first-line OSA treatment or stop current OSA treatment for 3 months; * Ability to follow directions and perform the required exercises; * Age between 18-65 yr. Exclusion Criteria: * Current use of OSA treatment; * Medical comorbidities that require restricting fluid intake (e.g., dysphagia, renal disease, liver disease, hyponatremia); * Severe nasal obstruction; 4) severe ankyloglossia; 4) craniofacial abnormality; 5) severe pulmonary disease; 6) severe post-traumatic stress disorder; 7) very severe insomnia; 8) body mass index (BMI) ≥30 kg/m2

What they're measuring

Apnea-Hypopnea Index (AHI)

Timeframe: From enrollment to end of three-month intervention

Trial details

NCT IDNCT07301710

SponsorUniformed Services University of the Health Sciences

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2027-09

Contact for this trial

Nancy P. Solomon, Ph.D.

301-319-7042 nancy.p.solomon.civ@health.mil