RecruitingNot Applicable

Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia

Greece100 participantsStarted 2026-03-15

Plain-language summary

This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia. The main question is : Does the HPI and AFM software reduce the incidence and duration of intraoperative hypotension? Does the HPI and AFM software optimize fluid and vasopressor administration? Does the HPI and AFM software improve perioperative outcomes? Participants will be randomly allocated to either an experimental group receiving goal directed hemodynamic therapy guided by HPI and AFM or a control group receiving conventional hemodynamic management.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> 18 years * Intraoperative monitoring \> 2 hours or general anesthesia \> 2 hours * Invasive arterial pressure monitoring * Target MAP ≥ 65 mm Hg intraoperatively * Written informed consent preoperatively * ASA Physical Status ≤ 4 Exclusion Criteria: * Target MAP other than 65 mm Hg * Severe preoperative hypotension (MAP \< 65 mm Hg) * Severe heart failure (e.g. LVEF \< 20%) * Emergency surgery

What they're measuring

Time-weighted average of intraoperative hypotension

Timeframe: Intraoperatively, starting 10 minutes after anesthesia induction or start of sedation

Trial details

NCT IDNCT07301307

SponsorNational and Kapodistrian University of Athens

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-10

Contact for this trial

Georgia Ntalamagka, MD

+306978210163 geo.dalamaga@gmail.com