RecruitingPhase 2

Clinical Efficacy and Mechanism Exploration of MR-61 in Delaying the Progression of Myopia

China164 participantsStarted 2025-10-01

Plain-language summary

To investigate whether probiotic MR-61 can assist in slowing down the progression rate of myopia (a prospective randomized controlled study).

Who can participate

Age range

3 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Myopia is defined as spherical equivalent (SE) ≤ -0.5D.
. Aged between 3 and 18 years, with no restriction on gender.
. Cylinder power ≤ 1.50D; anisometropia of SE between both eyes ≤ 1.50D.
. The subject has sufficient compliance with the study follow-up; the subject or their guardian has the intention to receive treatment and has signed the informed consent form.

Exclusion criteria

. Presence of other concomitant ocular diseases;
. Abnormal findings on clinical slit-lamp examination;
. Existence of amblyopia, manifest strabismus, esotropia, or other congenital ocular diseases;
. Individuals with abnormal intraocular pressure or abnormal axial length of the eye;
. Either or both parents having a spherical equivalent (SE) ≤ -6.00D;
. Other conditions inconsistent with this study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Spherical Equivalent Refraction

Timeframe: Measured at baseline, 1, 3, 6, 9, 12, 13, 14, 19, and 25 months post-intervention.

Trial details

NCT IDNCT07298824

SponsorSecond Affiliated Hospital of Nanchang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-07-01

Contact for this trial

Yifeng Yu, Ph.D

13979180258 171018170@qq.com

View on ClinicalTrials.gov More Myopia Progressing trials