To Compare the Effect of Closed Kinetic Chain and Isometric Exercises in Reducing Pain and Improv… (NCT07298798) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
To Compare the Effect of Closed Kinetic Chain and Isometric Exercises in Reducing Pain and Improving Functional Disability in Patients With Patellofemoral Pain Syndrome Associated With Knee Osteoarthritis
Pakistan70 participantsStarted 2023-11-09
Plain-language summary
Investigator study aims to compare the benefits of isometric exercise and closed kinetic chain exercises in strengthening programs to lessen pain along with enhance functionality in patients with PFP that are being associated with osteoarthritis and the assessment of PFP pertains to its recognition and the determination of significant therapeutic techniques. 70 Participants from the department of physiotherapy, Civil Hospital Karachi CHK and Dow University of Health Science (DIPMR) will be randomly assigned into two groups, an experimental group receiving closed kinetic chain exercise, and a control group receiving isometric exercises. The therapy will last four weeks, consisting of twelfth sessions. There will be 35 to 40 minutes in each session, Patients will be evaluated on primary outcome measure, pain intensity and functional limitation using various scales, including the numerical pain rating scale (NPRS) and Kujala/anterior knee pain scale (AKPS)
Who can participate
Age range
35 Years – 60 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Age between (35 to 60) years.
* Gender: female.
* The numerical pain rating scale (NPRS) is greater than three out often i.e. 3/10 score.
* Patient experiences anterior knee pain due to such activities like squatting, prolonged sitting, running and stair climbing.
* Patient with unilateral or bilateral knee pain with positive radiographic imaging.
* Patients have grade 1 and 2 knee osteoarthritis (K\&L classification).
Exclusion Criteria
* Any past record of knee surgery.
* Any past record of knee fracture.
* Patients with any neurological disorder.
* Cancer, malignancy or any bone tumor.
* Comorbid like diabetes mellitus.
* Any systemic inflammatory arthritis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing closed kinetic chain exercises versus isometric exercises for knee pain — given my specific mix of patellofemoral pain syndrome and knee osteoarthritis, which of these two exercise approaches does my doctor think is more likely to suit my current condition and fitness level?
2Since this trial is no longer actively recruiting, is there any way to access either of these exercise programs — closed kinetic chain or isometric — outside of the trial through my regular physical therapy care?
3The trial is measuring pain using the Numerical Pain Rating Scale and the Kujala Anterior Knee Pain Scale — can my doctor use those same tools to assess my pain and functional limitations now, so we have a baseline to track whether any treatment I start is actually working?
4This trial is listed as Phase NA, which typically means it's comparing two non-drug exercise therapies rather than testing a new medication — does my doctor think I should try one of these structured exercise programs before considering any other interventions like injections or surgery?
5Are there any risks associated with the closed kinetic chain or isometric exercises being studied in this trial that I should be aware of given the severity of my osteoarthritis, and would either type of exercise be off-limits for me??
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
numerical pain rating scale (NPRS)
Timeframe: 12th sessions for four weeks ,outcome measures will take place both, at the baseline when intervention start and four weeks, following the intervention
2
. Kujala/ Anterior knee pain scale (AKPS)
Timeframe: 12th sessions for four weeks, ,outcome measures will take place both, at the baseline when intervention start and four weeks, following the intervention