CompletedNot Applicable

A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes

United States254 participantsStarted 2025-12-15

Plain-language summary

The aim of this exploratory clinical study is to investigate the tooth whitening potential, Dentin Hypersensitivity (DH) efficacy, and oral tolerability of two experimental toothpastes in a DH population with appropriate tooth shade and dental stain levels for the evaluation of whitening performance.

Who can participate

Age range18 Years – 65 Years

SexALL

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Exclusion criteria

✕. Tooth with evidence of current/recent caries.
✕. Tooth with treatment for decay within 12 months of Screening (Visit 1) (self-reported).
✕. Tooth with exposed dentin and deep, defective or facial restorations.
✕. Tooth with a full crown or veneer.
✕. Tooth adjacent to a bridge abutment or crown which, in the opinion of the investigator or dentally qualified designee, could impact study outcomes.
✕. Sensitive tooth with contributing etiologies other than EAR to exposed dentin.
✕. Sensitive tooth not expected to benefit from use of an anti-hypersensitivity toothpaste, in the opinion of the investigator or dentally qualified designee.

What they're measuring

Mean VITA Shade Score at Baseline, Weeks 1, 2, 4 and 8

Timeframe: Baseline, Weeks 1, 2, 4 and 8

Mean Total Modified Lobene Stain Index (MLSI) Score at Baseline, Weeks 1, 2, 4 and 8

Timeframe: Baseline, Weeks 1, 2, 4 and 8

Trial details

NCT IDNCT07297732

SponsorHALEON

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2026-03-19

View on ClinicalTrials.gov More Dentin Hypersensitivity trials