Morning Versus Evening Patching in Childhood Amblyopia (NCT07294599) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Morning Versus Evening Patching in Childhood Amblyopia
100 participantsStarted 2025-12-14
Plain-language summary
To determine whether the time of day at which daily occlusion (patching) is administered - morning (08:00-10:00) versus evening (17:00-19:00) - affects the amount of visual-acuity improvement in the amblyopic eye in children with unilateral amblyopia.
Rationale:
While occlusion therapy remains the mainstay for treatment of childhood amblyopia, existing trials have focused on patching duration, not on the timing of occlusion. Diurnal or chronobiological factors - such as fluctuations in neuroplasticity, attention, compliance, or visual demand during the day - may influence the efficacy of patching. Understanding whether timing matters could help optimize occlusion therapy, improve outcomes, and reduce treatment burden.
Who can participate
Age range
4 Years – 8 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: 4-8 years.
* Unilateral amblyopia.
* Amblyopic-eye BCVA decimal 0.17-0.67 (≈ 6/36-6/9).
* Fellow-eye BCVA ≥ 0.80 decimal (≈ 6/7.5 or better).
* Amblyopia type: refractive-dominant or strabismic/mixed.
* Parent/guardian consent obtained.
Exclusion Criteria:
* Bilateral amblyopia.
* Sensory-deprivation amblyopia (e.g., due to congenital cataract, ptosis, corneal opacity).
* Ocular surgery within the past 6 months, or planned surgery during study.
* Likely poor adherence (e.g., due to social, logistic, or family constraints).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in best-corrected visual acuity (BCVA) of the amblyopic eye