ICSI Versus Conventional IVF in Couples With Unexplained Infertility (NCT07294027) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
ICSI Versus Conventional IVF in Couples With Unexplained Infertility
China848 participantsStarted 2026-01-01
Plain-language summary
This multicenter, open-label, parallel-group, randomized controlled trial aims to compare the live birth rate, fertilization outcomes, other pregnancy outcomes and safety between ICSI and conventional IVF among couples with unexplained infertility in China.
Who can participate
Age range
20 Years – 38 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Aged 20-38 years
. 18.5 \< BMI \< 24kg/m2
. Couples diagnosed with primary unexplained infertility:
. First IVF/ICSI cycle
. Received GnRH agonist protocol or GnRH antagonist protocol
. Willing to provide informed consent and comply with follow-up
Exclusion criteria
. Preimplantation genetic testing (PGT) cycles
. In vitro maturation (IVM) cycles
. Using donor sperm/oocyte
. Using frozen sperm/oocyte
. \<5 oocytes retrieved
. Abnormal semen parameters on the day of oocyte retrieval
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Live birth rate after the first embryo transfer cycle
Timeframe: At birth
Trial details
NCT IDNCT07294027
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University