Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema (NCT07294014) | Clinical Trial Compass
RecruitingNot Applicable
Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema
Turkey (Türkiye)32 participantsStarted 2026-01-01
Plain-language summary
Lipedema is a chronic adipose tissue disorder that commonly leads to joint laxity, hypermobility, and functional limitations, yet its impact on foot morphology has not been systematically examined. This case-control study aims to investigate whether patients with lipedema exhibit a higher prevalence of generalized joint hypermobility and foot structural abnormalities-specifically pes planus-compared with age- and BMI-matched controls. Using radiographic measurements (Meary angle and calcaneal inclination angle), clinical hypermobility assessment, and validated functional scales, the study seeks to determine the relationship between lipedema, hypermobility, and foot function.
Who can participate
Age range
18 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
General Inclusion Criteria (Apply to All Participants)
* Female participants
* Age 18 years or older
* Able to read and write (literacy requirement)
* Availability of bilateral lateral foot radiographs obtained within the past 1 year in the hospital PACS system
* Willing and able to provide written and verbal informed consent
Additional eligibility criteria for Lipedema Group
\- Clinical diagnosis of lipedema according to Halk and Damstra criteria.
Additional eligibility criteria for Control group:
* Female patients presenting with nonspecific foot pain
* Similar age and BMI range as the lipedema group
* No clinical diagnosis or suspicion of lipedema
Exclusion Criteria (Apply to all participants)
* Pregnancy
* Illiteracy
* Inability or unwillingness to provide written and verbal informed consent
* History of lower extremity fracture, trauma, or orthopedic surgery
* Diagnosis of diabetes mellitus
* Known rheumatologic disease
* Known polyneuropathy or peripheral nerve injury affecting the lower extremities
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.