Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness (NCT07291778) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness
United States100 participantsStarted 2026-12-01
Plain-language summary
This study will evaluate the use of the Venous Excess Ultrasound (VExUS) score to guide fluid management in critically ill ICU patients through a prospective, multi-aim design combining observational and randomized components. The study will be conducted in the medical intensive care unit (MICU), multidisciplinary critical care unit (MCCU), and cardiac care unit (CCU) at UAB.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults (≥18 years old)
* Admitted to the MICU, MCCU, or CCU within 24 hours of admission
* Acute kidney injury (AKI) (based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria)
* Adequate acoustic windows for a complete VExUS scan
Exclusion Criteria:
* \< 18 years old
* pregnant women
* End-stage renal disease (ESRD) or prior renal transplant
* Acute tubular necrosis (ATN) defined by urinalysis (≥2+ protein, ≥2+ blood, ≥1 muddy brown cast, ≥1 RBC cast, or ≥1 dysmorphic RBC)'
* Prior Whipple procedures
* currently incarcerated
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses something called VExUS — a Doppler ultrasound technique to detect venous congestion — to evaluate kidney injury in critically ill patients; can you explain what VExUS is and whether this kind of monitoring would apply to my situation?
2Since this trial is not yet recruiting, how long might it be before it actually opens, and are there any currently active studies or standard monitoring approaches that could address my kidney injury concerns in the meantime?
3The trial is measuring outcomes like the need for dialysis and whether kidney dysfunction persists after hospitalization — given my current condition, how likely am I to face those outcomes, and would being in this study change how aggressively my kidneys are monitored?
4This study is listed as Phase NA, which suggests it's observational rather than testing a new treatment — does that mean there's no experimental therapy involved, and if so, what would participating actually require of me day-to-day while I'm critically ill?
5Would you consider this trial's focus on early detection of venous congestion relevant to my care plan right now, even outside of the trial, or is this approach something my team is already using?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.