Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession (NCT07291583) | Clinical Trial Compass
CompletedNot Applicable
Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession
Turkey (Türkiye)40 participantsStarted 2025-07-01
Plain-language summary
This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be randomly assigned to receive CTG alone or CTG with adjunctive HA. Mean root coverage at 6 months is the primary outcome, while secondary measures include gingival thickness, clinical attachment level, esthetic scores, postoperative morbidity, and quality of life. The study aims to determine whether HA enhances soft tissue healing and root coverage predictability compared with conventional CTG.
Who can participate
Age range
18 Months
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Presence of at least one gingival recession defect classified as Cairo RT1 or Miller Class I-II with a minimum depth of 1 mm.
* Full-mouth plaque score (FMPS) and full-mouth bleeding on probing (FMBOP) \< 15%.
* Detectable cemento-enamel junction (CEJ).
* Age ≥ 18 years.
* No history of prior periodontal surgical treatment.
* Sufficient mental capacity to understand the study aims and procedures explained verbally and in writing.
* Determined to be cooperative and compliant with the clinician before, during, and after the surgical procedure.
Exclusion Criteria:
* Patients younger than 18 years.
* Periodontally healthy individuals.
* Current smokers.
* History of periodontal treatment within the past 1 year.
* Use of antibiotics within the past 3 months.
* Pregnancy or breastfeeding.
* Presence of systemic diseases such as diabetes, chronic kidney failure, cancer, bleeding disorders, connective tissue diseases, or other chronic conditions; and gingival recessions classified as Cairo RT3.
* Presence of cervical caries or restorations at the defect site.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Impact of Adjunctive Hyaluronic Acid on Mean Root Coverage After Recession Treatment
Timeframe: From enrollment to the end of treatment at 6 months"