Sensorimotor Integration in Patients With Tourette Syndrome (NCT07290920) | Clinical Trial Compass
CompletedNot Applicable
Sensorimotor Integration in Patients With Tourette Syndrome
Italy60 participantsStarted 2025-03-20
Plain-language summary
The present study investigates the mechanisms underlying the sense of agency in patients with Tourette Syndrome (TS). Previous research has shown that individuals with TS display impairments in both explicit and implicit aspects of agency, possibly due to altered integration between sensory feedback and motor predictions. To explore this hypothesis, the study will examine the phenomenon of sensory attenuation, a marker of sensorimotor integration that has not yet been investigated in this population. Furthermore, the study will assess how alterations in sensorimotor integration are related to the severity of TS symptoms.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
For Tourette Syndrome group:
* Clinical diagnosis of Tourette Syndrome (TS) according to DSM-5 criteria
* Age between 18 and 65 years
* Ability to understand and comply with study procedures
* Written informed consent provided
For Healthy Control group:
* No current or past history of neurological or psychiatric disorders
* Age between 18 and 65 years
* Matched to the TS group for age, sex, and education level
* Ability to understand and comply with study procedures
* Written informed consent provided
Exclusion Criteria:
* History of significant neurological disorders (e.g., brain injury or dementia) or major psychiatric disorders (with the exception of conditions commonly associated with Tourette Syndrome, such as Obsessive-Compulsive Disorder, ADHD, depression, and anxiety);
* Failure or refusal to provide written informed consent;
* Confirmed pregnancy (self-reported) and/or breastfeeding.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Magnitude of sensory attenuation (difference between self-generated and externally generated force reproduction)