Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms (NCT07290465) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms
Turkey (Türkiye)56 participantsStarted 2026-01
Plain-language summary
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.
The main questions it aims to answer are:
* Does the time of day (morning vs. evening) influence changes in pain perception following exercise?
* Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect?
Participants will:
* Complete questionnaires
* Undergo quantitative sensory testing
* Attend both morning and evening sessions in randomized crossover order
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy participants
* age 18 to 40 years
* good level of English that allow the enrolled participant to provide informed consent and complete the questionnaires provided
* being categorized as "moderate" in the International Physical Activity Questionnaire (IPAQ)
Exclusion Criteria:
* inability to report pain intensity reliably
* consumption of narcotics or tobacco products
* regularly taking pain medications and analgesics
* pregnant or planning to get pregnant
* surgery within the last 12 months
* acute or chronic pain conditions
* uncontrolled hypertension
* cardiovascular diseases, pulmonary diseases, neurological diseases with significant changes in somatosensory and pain perception, metabolic diseases, serious systemic diseases or conditions that restrict normal daily activities, inflammatory conditions (e.g. rheumatoid arthritis), or orthopedic injuries
* intolerable pain during the pain perception test
* serious psychiatric conditions (e.g., schizophrenia and bipolar disorder) or psychological disorders (e.g., depression) that may affect pain thresholds (16).
* Severe sleep disorders and circadian rhythm disturbances
* BMI \> 30
* serious fatigue or delayed-onset muscle soreness (9) at least 24 h after exercise sessions or a sudden change in activity for more than one week
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Pressure Pain Threshold (PPT)
Timeframe: Baseline (0 minute before intervention) and immediately post-intervention (within 2 minutes) Measured in both high intensity functional training (HIFT) and supervised deep-breathing conditions during each morning and evening session
2
Pressure Pain Tolerance (PPTol)
Timeframe: Baseline (0 minute before intervention) and immediately post-intervention (within 2 minutes) Measured in both high intensity functional training (HIFT) and supervised deep-breathing conditions during each morning and evening session