RecruitingNot Applicable

Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia

United States40 participantsStarted 2023-05-04

Plain-language summary

The purpose of this study is to look at children with PCD and see if they have another condition called "bronchial hyperresponsiveness".

Who can participate

Age range6 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Confirmed diagnosis of PCD per standard diagnostic criteria4 and positive genetics * Age greater than or equal to 6 years (no upper age limit) * Any gender or race * Able to perform pulmonary function testing (historical documentation of reversibility will be accepted) Exclusion Criteria: * history of current pneumothorax * inability to perform pulmonary function testing

What they're measuring

Bronchial Hyperresponsiveness prevalence

Timeframe: From spirometry baseline measurement (Visit 2) to completion of post-max bronchodilator test (Visit 2) (<1hr)

Bronchial Hyperresponsiveness prevalence

Timeframe: From spirometry baseline measurement (Visit 3) to completion of methacholine challenge test (Visit 3) (<1hr)

Bronchial Hyperresponsiveness prevalence

Timeframe: From spirometry baseline measurement (Visit 2) to completion of post-max bronchodilator test (Visit 2) (<1hr)

Bronchial Hyperresponsiveness prevalence comparison

Timeframe: From first Visit 2 baseline measurement of first subject enrolled to either: last Visit 3 visit of PCD subject who may complete Visit 3; or last Visit 2 visit of PCD subject or Healthy subject, whichever comes latest in enrollment (up to five years)

Trial details

NCT IDNCT07288827

SponsorIndiana University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-04-30

Contact for this trial

Fanmuyi Yang, PhD

317-274-8895 fy5@iu.edu

View on ClinicalTrials.gov More Primary Ciliary Dyskinesia trials