Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease (NCT07285642) | Clinical Trial Compass
RecruitingNot Applicable
Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease
Turkey (Türkiye)60 participantsStarted 2025-04-30
Plain-language summary
This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD). Functional near-infrared spectroscopy (fNIRS) and near-infrared spectroscopy (NIRS) will be used simultaneously to measure oxygenation changes in the prefrontal cortex and the vastus lateralis muscle during rest, Stroop task performance, the six-minute walk test, aerobic, strengthening, and breathing exercises.
The study will compare COPD patients and age- and sex-matched healthy controls to determine how brain and muscle oxygenation responses differ between groups and among exercise modalities. The findings are expected to guide the design of safe, individualized pulmonary rehabilitation programs that optimize oxygenation without compromising safety.
Who can participate
Age range
40 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Age 40-70 years
* Diagnosis of moderate-to-severe COPD (GOLD stage II-III)
* Stable disease (no exacerbation in previous 4 weeks)
* BMI 18.5-24.9 kg/m²
* Manual muscle strength ≥ 4 (MRC scale)
* Ability to perform exercise tests safely
* Written informed consent
Exclusion Criteria
* Severe comorbid conditions (uncontrolled cardiac, neurological, or orthopedic disease)
* Need for high-flow oxygen therapy (\>2 L/min)
* History of cerebrovascular disease or transient ischemic attack
* Musculoskeletal or dermatological conditions impairing NIRS measurement sites
* Restrictive lung disease, interstitial lung disease, or small-airway disease
* Participation in an exercise program within the last 12 months
Healthy Controls
* Age 40-70 years
* No acute or chronic disease
* Non-smoker
* BMI 18.5-24.9 kg/m²
* No musculoskeletal limitations
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.